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原著論文など

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KOIZUMI Akio(-2001)

A. 主な原著論文

1] Occupational and Environmental Health Sciences

1.Koizumi, A., Shiojima S., Ohmiya M., Nakano S. and Ikeda M. (1979) Acute renal failure and maneb [ manganousethylenebis (dithiocarbamate)] exposure. J. Am. Med. Assoc. 242: 2583-2585.

2.Koizumi A., Sekiguchi M., Konno M. and Ikeda M.(1980) Evaluation of the time weighted average of air contaminants
 with special reference to concentration fluctuation and biological half time. Am. Ind. Hyg. Assoc. J. 41 : 693-699.

3. Miyasaka, M. Kumai M., Koizumi A., Watanabe T., Kurasako K., Sato K. and Ikeda M.(1982) Biological monitoring of
  occupational exposure to methyl ethyl ketone by means of urinalysis for methyl ethyl ketone itself. Int. Arch. Occup. Environ. Health 50: 131-137.

4. Hasegawa, K., Shiojima S., Koizumi A. and Ikeda M.(1983) Hippuric acid and O-cresol in the urine of workers exposed ton toluene. Int. Arch. Occup. Environ. Health 52 : 197-208.

5.Koizumi A., Fujita H., Sadamoto T., Yamamoto Y., Kumai M. and Ikeda M.(1984) Inhibition of delta-aminolevulinic acid dehydratase by trichloroethylene. Toxicology 30 : 93-102.

6.Koizumi, A., Fujita H., Sadamoto T., Ohmachi T., Watanabe M. and Ikeda M.(1984) Cytochrome P-450 system dependent depression of delta-aminolevulinic acid dehydratase activity by bromobenzene. Toxicology 32 : 1-10.

7.Fujita, H., Koizumi A., Yamamoto M., Kumai M. and Ikeda M. (1984) Inhibition of delta-aminolevulinic acid
 dehydratase in trichloroethylene exposed rats, and the effects on heme regulation. Biochim. Biophys. Acta. 800: 1-10.

8.Koizumi, A, Sadamoto T., Naganuma H. and Ikeda M.(1984) Mechanism for modification of bromobenzene
 hepatotoxicity by coadministered toluene and chlorobenzene. Amer. J. Ind. Med. 6: 241-250.

9.Koizumi A., 1989 The potential of physiologically based pharmacokinetics to amalgamate kinetic data of trichloroethylenene and tetrachloroetylenene obtained various routes of exposure in rats and assessment of human risk posed by drinking water ingestion. Brit. J. Ind. Med. 46, 239-249.

10.Koizumi A. 1991 Experimental Evidence for the possible exposure of human workers to hexachlorobenzene by skin contamination. Brit. J. Ind. Med. 48, 622-628.

11.Koizumi A.,Saitoh N., Suzuki T. and Kamiyama S. (1994) A novel compound, 9-hydroxy-1-nitropyrene, is a major photodegraded compound of 1-nitropyrene in the environment. Arch. Environ. Health 49: 87-92.

12. Koizumi A., Aoki T., Tsukada M., Naruse M. and N. Saitoh (1994)
 Mercurynot sulphur dioxide, poisoning as cause of smelter disease in industrial plants producing sulphuric acid. 
Lancet 343, 1411-1412.

13.Sasaki M., Mogi T., Wada Y., Hirosawa I., and Koizumi A. (1996) An endemic condition of biochemical hypohglycemia among male volunteers. Ind Health, 34: 323-334.

14. Mogi T., Wada Y., Hirosawa I., Sasaki M. and Koizumi A. (1996) Epidemiological study on hypoglycemia endemic to female nurses and other workers. Ind Health, 34: 335-346.

15. Koizumi Akio, Katahiira Masayuki, Sekiguchi Takeshi, Yasunobu Shiota (2000) Log-normality of air contaminants and its hidden chracteristics useful for industrial hygiene technology. JOH 42:281-283

16. Xiaofei E, Yasuhiko Wada, Jun-ichi Nozaki, Hiroyuki Miyauchi, Shigeru Tanaka, Yukio SEKI and Akio Koizumi (2000) A linear pharmacokinetic model predicts usefulness of N-methyl-2-pyrrolidone (NMP) in plasma or urine as a biomarker for biological monitoring for NMP exposure, JOH 42: 321-327.

2] Genetics

1.Koizumi A., Walford R.L. and Imamura T.(1986) Treatment of poly IC enhances lipid peroxidation and the activity of xanthine oxidase and decreases hepatic P-450 content and activities in mice and rats. Biochem. Biophys. Res. Comm. 134 : 532-637.

2.Koizumi A., Hasegawa L., Thomas I.K. and Imamura T.(1986) The effect of induction of T-cell-dependent antibody with sheep red blood cell on P-450-dependent and independent xenobiotic metabolizing enzymes. Biochem. Pharmacol. 35, 2743-2748.

3.Koizumi, A., Rodgers K.E., Ali B., Walford R.L. and Imamura T.(1986) Influence of aging and H-2 haplotypes on poly IC induced inhibition of mixed function oxidase. In " liver and Aging". Elsevir Scientific Publishers. Amsterdam, Netherland.

4.Koizumi, A, Hasegawa L., Rodgers K.E., Ellfson D., Walford R.L. and Imamura T.(1986) Influence of H-2 haplotypes on poly IC induction of xanthine oxidase and poly IC induced decreases in P-450 mediated enzyme activities. Biochem. Biophsy. Res. Comm. 138, 246-253.

5.Koizumi A., Hasegawa L., Walford R.L. and Imamura T.(1986) Influence of H-2 locus on inducibility of P-450
 mediated monooxygenase activities studied in H-2 congenic mice. Mech. Ageing Develop. 37, 119-136.

6.Koizumi A., Walford R.L. and Hasegawa, L. 1987 Differences in H-2 recombinant mice in the
-naphthoflavone inducibility of the mixed function monooxygenase, P1-450. Immunogenetics 26, 169-174.

7.Koizumi A., Tsukada M., Wada Y. and Sigetosi Kamiyama. 1989 Demonstration of a new mouse mammary tumor virus locus in the genome of the mammary tumor prone strain SHN mouse. Biochem. Biophsy. Res. Comm. 166, 336-341.

8.Naruse M., Tsukada M., Koizumi A. (1996) A novel endogenous mouse mammary tumor virus locus in Asian wild mice and its evolutionary divergency. Zool. Sci. 13:299-302.

9.Yoshioka M, Kayo T, Ikeda T, and Koizumi A (1997) A novel locus, Mody 4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice. Diabetes 46: 887-894

10.Koizumi A, Nomiyama T, Tsukada M, Wada Y, Omae K, Tanaka S, Miyauchi H, Imamiya S, Sakurai H.(1998)Evidence on N-acetyltrasnferase allele associated metabolism of hydrazine in Japanese Workers. J. Occup. Environ. Health 40: 217-222.

11.Kayo T and Koizumi A. (1998) Mapping of murine diabetogenic gene Mody on chromosome 7 at D7Mit258 and its involvement in pancreatic islet and
β cell development during the perinatal period. J. Clin. Invest.101: 2112-2118

12.Shoji Y.,Koizumi A.,Kayo T.,Ohata T,Takahashi T, Harada K, Takada G. (1998) Evidence for linkage of human primary systemic carnitine deficiency with D5S436; a novel gene locus on chromosome 5q. Am J Hum. Genet.63:101-108

13.Nomiyama T., Omae K., Tanaka S., Miyauchi H., Koizumi.A., Tsukada M Wada Y., Mogi T., Imamiya S., Sakurai H.(1998) A cross sectional observation of the effects of hydrazine hydrate on workers' health. J Occup Health. 40:184-192

14.Nomiyama T, Omae K, Tanaka S, Miyauchi H, Koizumi A, Tsukada M, Wada Y, Mogi T, Imamiya S, Sakurai H. (1998) A cross- sectional obsrvation of the heath effects of hydrazine hydrate and differences of its metabolism by NAT2 poymorphism. Int Arch Occup Environ Health.71:33-36

15. Ohata T, Koizumi A, Kayo T, Shoji Y, Watanabe A, Monoh K, Higashi K, Ito S, Ogawa O, Wada Y, and Takada G. (1998) Evidence of an increased risk of hearing loss in heterozygous carriers in a Wolfram syndrome family. Hum Genet 103:470-474.

16.Nezu J, Tamai I, Oku A, Ohashi R, Yabuuchi H, Hashimoto N, Nikaido H, Sai Y, Koizumi A, Shoji Y, Takada G, Matsuishi T, Yoshino M, Kato H, Ohura T, Tsujimoto G, Hayakawa J, Shimane M, Tsuji A.( 1999) Primary systemic carnitine deficienccy is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter. Nat. Genet.21:91-94

17. Wang J, Takeuchi T, Tanaka S, Kubo S-K, Kayo T, Lu D, Takata K, Koizumi A, and Izumi T (1999) A mutation in the insulin 2 gene induces diabetes with severe pancreatic
β
-cell dysfunction in the Mody mouse. J Clin Invest 103: 27-37.

18. A.Koizumi, J. Nozaki, T. Ohura, T. Kayo, Y. Wada, J.Nezu, R. Ohashi, I. Tamai, Y. Shoji, G. Takada, S.Kibira, T. Matsuishi and A. Tsuji (1999) Genetic epidemiology of carnitine transporter OCTN2 gene in a Japanese population and phenotypic characterizations in Japanese pedigrees with primary systemic carnitine deficiency. Human Molec. Genet.8:2247-2254

19. Kubota T, Hara M, Nozaki J, Manabe M, Koizumi A.(2000) Probable involvement of a germ-line mutation of an unknown mismatch repair gene in a Japanese Muir-Torre sundrome phenotype. J. Dermatol. Sci. 23:117-125

20. Habuchi T, Suzuki T, Sasaki Ryusei, Kizhong Wang, Sato Kazunari, Satoh Shigeru, Akao Toshiya, Tsuchiya N, Shimada Naotake, Wada Yasuhiko Koizumi Akio, Chihara Junnichi, Ogawa Osamu, Kato Teturou.(2000) Association of Vitamin F recptor gene polymorphisms with prostata cancer and benign prostatic hyperplasia in a Japanese population. Cancer Res. 60: 305-308.

21. Noguchi Atusko, Shoji Yutaka, Akio Koizumi, Takahashi Tsutomu, Shoji Yashuko, Matsumori Mika, Kayo Tsuyoshi, Tomoaki Ohhata, Yashuhiko Wada, Yoshimura Ihoko, Maisawa Shunichi, Konishi Mineo, Takasago Yuhei, Takada Goro (2000) SLC7A7 gemonic structure and novel variants in three Japanese lysinuric prootein intolerance families. Human Mutation. 15:367-372.

22. Kayo T, Fujita H, Nozaki J, E X, Koizumi A Identification of two chromosomal Loci determining glucose intolerance in a C57BL/6 mouse strain.(2000) Comparative Medicine 50, 296-302.

23. Akio Koizumi, Yutaka Shoji, Jun-nichi Nozaki, Atsuko Noguchi, Xiaofei E, Dakeishi Miwako, Ohura Hirotoshi, Kayo Tsuyoshi, Wada Yasuhiko, Motomu Manabe, Yuhei Takasagao, Goro Takada and the mass screening group.(2000) Excesive clustring of lysinuric protein intolerance (ILP) patinets in a nothermn part of Japan due to a founder effect. Hum Mutat 16:270-1

24. Fujita H, Haseyama T, Kayo T, Nozaki J, Wada Y, Ito S, Koizumi A. Increased expression of glutathione S-transferase in renal proximal tubules in the early stages of diabetes: a study of type-2 diabetes in the Akita mouse model.Exp Nephrol. 2001;9(6):380-6.

25. Takahashi T, Nozaki J, Komatsu M, Wada Y, Utsunomiya M, Inoue K, Takada G,Koizumi A. A new locus for a dominant form of multinodular goiter on 3q26.1-q26.3. Biochem Biophys Res Commun. 2001;284:650-4.

26. Nozaki J, Dakeishi M, Ohura T, Inoue K, Manabe M, Wada Y, Koizumi A. Homozygosity mapping to chromosome 5p15 of a gene responsible for Hartnup disorder. Biochem Biophys Res Commun. 2001;284(2):255-60.

3] Energy Restriction and/or Aging

1.Koizumi A., Weindruck R. and Walford R.L.(1987)Influence of Dietary Restriction on liver enzyme activities and lipid peroxidation in mice. J. Nutr. 117, 361-367.

2.Crew M.D., Spindler S.R., Walford R.L. and Koizumi A. 1987 Age-related decrease of growth hormone and prolactingene expression in the mouse pituitary. Endocrinology 121, 1251-1255.

3.Spindler S.R. , Koizumi A., Walford R.L.and Mote P.L. 1989 P1-450 and P3-450 gene expression and maximum life-span in mice. 1989 Mut. Res. 219, 89-94.

4.Koizumi A., Wada Y., Tsukada M., Hasegawa J. and Walford R.L. 1989 Low Blood glucose levels and small islets of Langerhans in the pancreas of caloric restricted mice. Age, 12, 93-96.

5.Koizumi A., Wada Y., Tsukada M., Kamiyama S. and Weindruch R. 1990 Effects of caloric restriction on mouse mammary tumor mRNA levels in uterus, uterine hyperplasia and primary histology in C3H/SHN F1 mice. J. Nutr.120,1401-1411.

6.Tsukada M., Wada Y., Hamade N. and Koizumi A. 1991 Stable Lyonization of X-linked pgk-1 gene during in normal tissues and tumors of mice carrying Searle's translocation. J. Gerontol. 46, B213-216.

7.Koizumi A., Wada Y., Tsukada M. and Kamiyama S. 1992 Inhibition of tumor growth by energy restriction.In New Horizons in aging science. ed( Orimo H, Fukuchi Y, Kuramoto K, and Iriki M) Published from Tokyo University Press pp78-79.

8. Koizumi A., Tsukada M., Wada Y., Masuda H. and Weindruch R. 1992 Mitotic activity in mice is suppressed by energy restriction induced torpor. J. Nutr. 122, 1446-1453.

9. Wada Y., Tsukada M., Kamiyama S. and Koizumi A. 1993 Retroviral gene expression as a possible biomarker of aging. Int. Arch. Occup. Environ. Health 65: S235-240.

10.Myaura Y., Tawa R., Koizumi A., Uehara Y., Kurishita A., Sakurai H., Kamiyama S., Ono T 1993 Effects of energy restriction on age-associated changes of DNA methylation in mouse liver. Mutation. Res. 295:63-69.

11.Tsukada M., Hamade N., Wada Y., Mogi T. Kamiyama S., Koizumi A(1993) Energy restriction suppresses microsomal Ca++-ATPase activities in various organs in C57BL/6 female mice in both euthermic and torpor states. Mech. Ageing Develop. 68:183-189.

12.Koizumi A., Tsukada M., Hirano S., Kamiyama S., Masuda H., and K.T. Suzuki (1993) Energy restriction which suppresses spontaneous and asbestos-induced adenocarcinoma in A/J mice decreases labeling indices in various organs by inducing torpor. Lab. Invest.68:728-739.

13. Wada Y., Shinbo A., Tsukada M., Iijima T. and Koizumi A. Electrophysiologiccal evidece on increase in cold tolerance of cardiac muscles in mice after energy restriction. Mech. Ageing Develop.97, 35-43, 1997.

14. Abe T, Nakajima A, Satoh N, Ohkoshi M, Sakuragi S, Koizumi A. Suppression of experimental autoimmune uveoretinitis by dietary calorie restriction. Jpn J Ophthalmol. 2001 Jan-Feb;45(1):46-52.

B.主な総説

.小泉 昭夫. 高齢化社会における医学。日本医師会雑誌。113、989ー993。

. Koizumi A. (1994) Fighting myths. Lancet 344, 559-560.

.小泉昭夫,茂木隆.(1996)有害物質暴露による毒性健康影響評価に関わる情報ネットワークと情報科学.産業医学レビュー,9119-38.

4.小泉 昭夫. Establishment of evidence based health care for common diseases based on genetic epidemiological approach. 日本衛生学雑誌 2003 May;58(2):260-6

.主な著書

1.Koizumi Akio TYPES OF CHEMICALS in Encyclopedia of life support system. Unesco

2.小泉 昭夫 自然環境と老化. 折茂 肇(編集代表)新老年学 2. 東京大学出版会、東京、pp 209-215 平成111.

3.小泉 昭夫 糖尿病 松島網治(編集代表)分子予防医学 医学書院、東京、pp266-274

4.小泉 昭夫 環境衛生I 近藤喜代太郎(編集代表)公衆衛生学 放送大学、東京

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